IHTM Department of chemistry
Research

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Still working
       Department of Chemistry is a part of
      Institute of Chemistry, Technology and Metallurgy
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The focus of fundamental and applied research in organic synthesis is the design of new chemical reactions, and their application in total syntheses of complex organic compounds: natural products, pharmacologically significant compounds etc. Also, research directed to synthetic transformations of carbon C60, new, recently discovered allotropic modification of carbon, considered to find application in various aspects of advanced technologies in near future (organic superconductors, optical fibers, plastics with extraordinary properties etc.) has recently been initiated.

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Development of procedures for synthesis of steroid hormones and antihormones
Steroid hormones and antihormones have a very important role in hormonal therapies of various diseases. Their synthesis is very significant for pharmaceutical industry. We have used both chemical synthesis and biotechnological techniques for the development of an efficient procedure for preparation of estrone, starting from diosgenin, and of mifepristone, starting from estrone.

Synthesis and activity study of new bioisosteric analogues of dopamine
Dopamine is an endogenous catecholamine with an important role in regulation of functions of central nervous system, endocrine system and peripheral nervous system. Disturbances of function of the dopaminergic system is related to various pathological states, such as: psychoses, schizophrenia, parkinsonism, dependence disorders (alcoholism, drug abuse), hypereprolactinemia and cardiovascular disorders. Chemical, pharmacodynamic and pharmacokinetic properties of dopamine prevent its direct use in therapy of such disorders. Therefore, there is a great need for new substances that could regulate the activity level of the dopaminergic system in the organism. Our work encompasses synthesis and activity study of new dopaminergic ligands whose structures are shown in the scheme. Some of them have affinities of 1 to 10 nM, comparable to the most potent dopaminergic ligands, It makes them possible candidates for new pharmaceuticals. Pharmacological investigations of these substances in vivo are under way.

More will be added in the future...

(c)Mario Zlatoviæ