[dr Milan R. Nikolic]

Faculty of Chemistry, Studentski trg 12-16, Beograd
Department of Biochemistry

Phone:   011 3336 657

Office:   420

Laboratory:   249A

E-mail:   mnikolic@chem.bg.ac.rs

Personal data

Born on September 28, 1971 in Zaječar, Serbia. Single. Speaks Serbian and English language.

Education and qualifications

1991-1996: Undergraduate studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1996-2002: Master of science studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2002-2010: Doctoral academic (PhD) studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

History of employment

1996: Junior associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1996-1997: Teaching assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1998: Associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1998-1999: Teaching assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1999-2003: Graduate assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2003-2010: Assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2010-2013: Scientific associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2013-2021: Assistant professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2021: Associate professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

Scientific interest

Biochemistry of colored proteins and their chromophores - structure, activity, roles, bioactive properties; possibilities of application in biochemical education.

Effects and mechanisms of pleiotropic action of drugs (psychopharmaceuticals, statins, antidiabetics).

Awards and merits

December 18, 2023: Medal for outstanding results in teaching (Serbian Chemical Society)

Other activities

Member of Serbian Biochemical Society from 1998. (former Yugoslav Biochemical Society)

Member of Serbian Chemical Society from 2000.

Member of the Committee for Admision to Basic and Integrated Studies from June 9, 2016 till June 13, 2019.

Member of the Committee for Admision to Basic and Integrated Studies from June 13, 2019 till May 12, 2022.

Member of the from January 14, 2021.

Member of the Ethical Committee for Use of Human Biological Matherial in Research from July 12, 2021.

Member of the Committee for Promotion of the Faculty of Chemistry from November 10, 2021 till January 10, 2024.

Member of the Committee for Admision to Basic and Integrated Studies from May 12, 2022.

Member of the Publishing Center Council from January 12, 2023.

Member of the Committee for Promotion of the Faculty of Chemistry from January 11, 2024.

Educational activities

Participation in research projects

Active projects:

Finished projects:

  • 2011: Rational Design and Synthesis of Bioactive and Coordination Compounds and Functional Materials Relevant for (bio)Nanotechnology – 172035
    project type:   National Fundamental Research Projects
    project is funded by: Ministry of Science and Technological Development (Belgrade, Serbia)

Author identification numbers

Representative references

Izabrani radovi / Selected papers:

A. Simović, S. Combet, T. Ćirković-Veličković, M. Nikolić, S. Minić. Probing the stability of the food colourant R-phycoerythrin from dried Nori flakes. Food Chem, 2021; 374:131780. doi: 10.1016/j.foodchem.2021.131780

M. Šunderić, T. Vasović, M. Milčić, Č. Miljević, O. Nedić, M. Nikolić, N. Gligorijević. Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein. Int J Biol Macromol. 2021;183:502-512. doi: 10.1016/j.ijbiomac.2021.04.155

N. Gligorijević, S. Minić, M. Radibratović, V. Papadimitriou, O. Nedić, T. Sotiroudis, M. Nikolić. Nutraceutical phycocyanobilin binding to catalase protects the pigment from oxidation without affecting catalytic activity. Spectrochim Acta A Mol Biomol Spectrosc. 2021;251:119483. doi: 10.1016/j.saa.2021.119483

L. Platanić Arizanović, A. Nikolić-Kokić, J. Brkljačić, N. Tatalović, M. Miler, Z. Oreščanin-Dušić, T. Vidonja Uzelac, M. Nikolić, V. Milošević, D. Blagojević, S. Spasić, Č. Miljević. Effects of several atypical antipsychotics closapine, sertindole or ziprasidone on hepatic antioxidant enzymes: Possible role in drug-induced liver dysfunction. J Toxicol Environ Health A. 2021;84(4):173-182. doi: 10.1080/15287394.2020.1844827

N. Gligorijević, T. Vasović, S. Lević, Č. Miljević, O. Nedić, M. Nikolić. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. Int J Biol Macromol. 2020;154:142-149. doi: 10.1016/j.ijbiomac.2020.03.119

M. Nikolic, S. Minic, M. Macvanin, D. Stanic-Vucinic, T. Cirkovic Velickovic. Chapter 8: Analytical Protocols in Phycobiliproteins Analysis. Book: Pigments from Microalgae Handbook. E. Jacob-Lopes et al. (Eds.). Springer Nature Switzerland AG 2020. doi: 10.1007/978-3-030-50971-2_8

L Arizanovic, S Spasic, C Miljevic, MB Spasic, M Nikolic. A Case Report of Exacerbation of Leg Ulcers Associated with Acute High-dose Acetylsalicylic Acid in a Patient with Klinefelter Syndrome. Cureus. 2019;11(12):e6449. doi: 10.7759/cureus.6449

T. Uzelac, A. Nikolić-Kokić, S. Spasić, M. Mačvanin, M. Nikolić, Lj. Mandić, V. Jovanović. Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content. Chem Biol Interact. 2019;311:108787. doi: 10.1016/j.cbi.2019.108787

D. Stanic-Vucinic, S. Minic, M. Nikolic, T. Cirkovic Velickovic. Chapter 7: Spirulina Phycobiliproteins as Food Components and Complements. Book: Microalgal Biotechnology. E. Jacob-Lopes, L. Queiroz Zepka, & M. I. Queiroz (Eds.). IntechOpen 2018. doi: 10.5772/intechopen.73791

L. Breberina, M. Zlatović, M. Nikolić, S. Stojanović. Computational Analysis of Non-covalent Interactions in Phycocyanin Subunit Interfaces. Mol Inform. 2019;38(11-12):e1800145. doi: 10.1002/minf.201800145

M. Radibratović, S. Minić, D. Stanić-Vučinić, M. Nikolić, M. Milčić, T. Ćirković Veličković. Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study. PLoS One. 2016;11(12):e0167973. doi: 10.1371/journal.pone.0167973 

S. Minic, D. Stanic-Vucinic, J. Mihailovic, M. Krstic, M. Nikolic, T. Cirkovic Velickovic. Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue colored biliprotein of microalga Spirulina. J Proteomics. 2016;147:132-139. doi: 10.1016/j.jprot.2016.03.043

S. Minić, M. Milčić, D. Stanić-Vučinić, M. Radibratović, T. Sotiroudis, M. Nikolić, T. Ćirkovic Veličković. Phycocyanobilin, a bioactive tetrapyrrolic compound of blue-green alga Spirulina, binds with high affinity and competes with bilirubin for binding on human serum albumin. RSC Adv. 2015;5:61787-61798. doi: 10.1039/C5RA05534B