Research work at the Department of Organic Chemistry is carried out in several areas that intertwine and build on each other.
Development of catalytic synthetic methodologies, such as organocatalyzed reactions and transition-metal-catalyzed reactions represent a significant part of research in the field of organic chemistry.
In addition, the total synthesis of natural biologically active molecules and the synthesis of their structural analogues in order to develop more active derivatives are also an important part of the research carried out within the Department.
Special attention is devoted to the development of methodology for the synthesis and derivatization of heterocyclic compounds in order to efficiently obtain highly functionalized molecules, as well as to understand the mechanistic pathways for their formation.
A special area of research at the Department includes the design, synthesis and study of the supramolecular organization of voluminous and planar structures in order to obtain molecular machines and functional nanomaterials.
Isolation, characterization and evaluation of the biological activity of secondary metabolites from plants, fungi, centipedes, insects, as well as the study of the chemotaxonomy of the investigated species, is another area on which the members of the Department are focused.
Part of the research in medicinal chemistry involves the design and synthesis of libraries of compounds active against eukaryotic pathogens, viruses, bacteria and cancer cells. In addition to the synthesis, research is also focused on understanding the mechanisms of action of compounds in biological systems.