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Course code:

Course name:
Chemistry of Heterocycles

Academic year:


Attendance requirements:

200A1 + 200E1



Study level:

basic academic studies

Study programme:

Chemistry: 3. year, winter semester, compulsory course


Igor M. Opsenica, Ph.D.
associate professor, Faculty of Chemistry, Studentski trg 12-16, Beograd


Vladimir D. Ajdačić
associate researcher, Innovation center, Studentski trg 12-16, Beograd

Andrea M. Nikolić
teaching assistant, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: two hours of lectures + two hours of labwork (2+0+2)


To introduce students to the traditional and modern methods in the field of chemistry of heterocycles.


Understanding the structure, properties and reactivity of some classes of heterocyclic compounds. Ability to conduct research in the field of synthesis of heterocyclic compounds which are needed in medicinal chemistry and chemistry of natural products.

Teaching methods:

Lectures, laboratory classes.

Extracurricular activities:


  • I. Opsenica: Hemija heterocikličnih jedinjenja I, Hemijski fakultet, Univerzitet u Beogradu, 2016. ISBN: 978-86-7220-079-9
  • J. A. Joule, K. Mills: Heterocyclic Chemistry, Wiley-Blackwell, 2010. ISBN 978-1-405-13300-5

Additional material:

Course activities and grading method


0 points (2 hours a week)


  1. Introductory lecture.
  2. Nomenclature of heterocyclic compounds.
  3. Saturated heterocyclic compounds.
  4. Pyrrole.
  5. Furan.
  6. Thiophene.
  7. Indole.
  8. Benzo[b]furan.
  9. Benzo[b]thiophene.
  10. Pyridine.
  11. Quinoline.
  12. Methodological approach in the synthesis of natural products and biologically active heterocyclic compounds.


30 points (2 hours a week)


Experimental exercises include the realization of five preparations which represent an experimental illustration of the subject matter covered within the lectures. The preparations include the synthesis and transformation of certain classes of heterocyclic compounds which have been described in the literature. Apart from that, within experimental exercises students learn about the basic techniques for isolation and purification of synthesized compounds.

  1. Non-aromatic heterocyclic compounds.
  2. Pyrrole.
  3. Furan.
  4. Thiophene.
  5. Indole.
  6. Benzo[b]furan.
  7. Benzo[b]thiophene.
  8. Pyridine.
  9. Quinoline.

Written exam:

40 points

Oral exam:

30 points

Wed Apr 24 16:29:17 2019

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